Figure 2
From: Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice
A genome scan showing a significant QTL on chromosome 5 that maps to the cell death phenotype. The microsatellite mapping data was analyzed individually for male and female mice, and for all the mice with and without sex as an interactive covariate. The observed LOD score was compared to 10000 LOD scores with permuted phenotypes [61], yielding a 5% significance threshold of 4.15. The inset shows a detail of the LOD scores for all 3 markers used for chromosome 5 (Chr5). The region of interest maps between 34 and 59 cM with the predicted maximum LOD score (5.825) at 38 cM. This locus has been designated as Retinal ganglion cell susceptible 1 (Rgcs1).