Reaction time. Mean (± SE) reaction time (RT) across subjects (N = 16), as a function of precue onset and stimulation time. The RT difference between the late- and the early-precue condition strongly suggests that at least parts of the thumb movement were programmed before the response signal occurred. The early-precue trials without TMS were also compared to early-precue trials with TMS. The post-hoc comparisons showed that TMS reduced the reaction times even further, and that this reduction was stronger the earlier the TMS pulse was applied. **p < 0.01.