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Table 1 List of cervical cord lesioned and intact monkeys included in the present study with identification code (same as in [10]).

From: Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion

 

Mk-AG

Mk-AT

Mk-AF

Mk-AC

Mk-AM

Mk-CS

Mk-CB

Mk-CC

Mk-CH

Mk-IR

Mk-IE

Mk-IZ

Mk-IRh

Mk-IG

species

fasc.

fasc.

mul.

fasc.

fasc.

mul.

fasc.

fasc.

fasc.

mul.

mul.

fasc.

mul.

mul

Antibody Treatment

Anti-Nogo-A (hNogo)

Anti-Nogo-A (hNogo)

Anti-Nogo-A (11C7)

Anti- Nogo-A (hNogo)

Anti-Nogo-A (hNogo)

Contr.

Contr.

Contr.

Contr.

-

-

-

-

-

Hemi-section total extent (%)

78

*

56

85

80

63

75

38

90

-

-

-

-

-

Completeness of dorsolateral funiculus section

Yes

*

Yes

Yes

Yes

Yes

Yes

No

Yes

-

-

-

-

-

RS and CS lesion extent (%)

100

*

73

100

100

87

93

61

100

-

-

-

-

-

Functional Recovery (%)

100

(100)*

57

100

96

22

78

83

53

-

-

-

-

-

Completeness of CS/RS section

Yes

*

No

Yes

Yes

Yes

Yes

No

Yes

-

-

-

-

-

Survival time after lesion (in days)

112

97

144

135

138

198

225

105

138

-

-

-

-

-

ICMS

no

no

yes

no

no

yes

no

yes

no

no

no

no

no

no

  1. At the time of the experiment, the lesioned monkeys had different names, not indicating whether the animal was infused with the control or the anti-Nogo-A antibody, corresponding to a double blind procedure (except Mk-AF, Mk-CS and Mk-CC). New names were assigned to the monkeys during the writing of the manuscript to improve its readability, in consistency with [10].
  2. Under species, "mul." is for macaca mulatta while "fasc." is for macaca fascicularis.
  3. The five anti-Nogo-A antibody treated monkeys are in the five leftmost columns ("Anti-Nogo-A") with indication of which of the two antibodies was used (mAB11C7 or mAB hNogo-A), whereas the four control antibody treated monkeys ("Contr.") are in the next four columns. The five intact monkeys are in the five rightmost columns.
  4. Total hemi-section extent was calculated as the percentage of corresponding hemi-cord affected by the lesion on the frontal reconstruction of the cervical cord.
  5. To tentatively determine more precisely the extent of the RS and CS lesions a quadrant of the lateral funiculus in the white matter was outlined going from the dorsal to the ventral rootlet zone. This was indicated as RS and CS lesion extent.
  6. Functional recovery was assessed here for manual dexterity based on the "modified Brinkman board" task (see [10]), by giving in percent the ratio of the post-lesion score to the pre-lesion score.
  7. In the row "completeness of RS section", "No" and "Yes" indicates whether the RS transection was considered as partial or as complete, respectively (for further explanation see text).
  8. Survival time: number of days separating the cord hemi-section from the sacrifice of the animal.
  9. * In this animal the total hemi-section extent and consequently also the RS and CS extent could not be calculated for technical reasons (poor quality of histology). In addition in this same animal the lesion was too caudal and thus the 100% functional recovery cannot be interpreted.
  10. ICMS is for intracortical microstimulation. "Yes" means that the corresponding monkeys were subjected to extensive ICMS both pre- and post-lesion in order to study the change of motor maps (somatotopy) in relation to the lesion (see [9, 28]).
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BMC Neuroscience

ISSN: 1471-2202

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