Figure 2
From: Carbenoxolone induced depression of rhythmogenesis in the pre-Bötzinger Complex
Glycyrrhizic acid and Carbenoxolone differentially affect I Na . A. Representative Traces from whole-cell voltage clamp experiments demonstrating the lack of change in peak INa over time in aCSF or GZA (50 μM) vs. increased peak INa in CBX (50 μM). Black trace represents control conditions and red trace represents drug effect. Vertical scale bars = 1 nA; time bar represents 1 ms. B. Current-Density vs. voltage relationships under baseline (t = 0 min) and after 20 min in the indicated treatment. Whereas GZA (50 μM) produced no consistent change in INa CBX (50 μM) increased the density of this current. C. Current density evoked during voltage steps from -60 to -30 mV. a: different from baseline (t = 0 min) at P < 0.05; b: different from aCSF at P < 0.05; c: different from GZA at P < 0.05. The numbers within each column represent sample size.