Enhanced nigrostriatal neuron-specific, long-term expression by using neural-specific promoters in combination with targeted gene transfer by modified helper virus-free HSV-1 vector particles

Table 3 The numbers of β-gal or PkcΔGG positive cells that contained TH-IR, in rats sacrificed at 4 days after co-injection of pINS-TH-NFHlac/gC – gdnf and pHSVpkcΔGG/gC – gdnf into the midbrain

	Numbers of positive cells		%	Numbers of positive cells		%
Rat	β-gal-IR	TH-IR	Costained	Flag-IR	TH-IR	Costained
1	471	378	80	535	344	64
2	758	625	83	652	467	72
3	444	384	87	474	316	67
Average			83 ± 2			68 ± 2

This experiment was performed as in Table 1, except a mixture of equal titers of pINS-TH-NFHlac/gC – gdnf and pHSVpkcΔGG/gC – gdnf was injected into the midbrain.

ISSN: 1471-2202