Comparative analysis of protein profiles from synaptosomes obtained from CA3-CA1 cultured cells and CA3-CA1 hippocampal brain tissue. A) Exemplar protein profiles of the synaptosomes from CA3-CA1 cultures (left), and CA3-CA1 hippocampal tissue (right), separated by two-dimensional gel electrophoresis and silver stained. B) Distribution of spot intensities (black histograms) and background noise (grey histograms) from the same 2D gels in panel A from cultures (upper panel) and hippocampal tissue (lower panel). C) Some exemplar proteins whose expression differed between the two samples. TPIS: Triosophosphate isomerase; ACOM: mitochondrial aconitase; PEBP1: Phosphatydilethanolamine-binding protein 1; GMFB: Glial maturation factor beta; TCTP: translationally controlled tumor protein (see also table 1).