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Figure 1 | BMC Neuroscience

Figure 1

From: Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis

Figure 1

Myelination in the zi/zi hindbrain. Coronal sections of the pons from zi/zi (B, D, F, H) or control SD (A, C, E, G) rats at P5 were immunostained with antibodies for Rip. A, B , Medial vestibular nuclei, the developing grey matter in the dorsal region of pons. A large number of Rip-positive promyelinating oligodendrocytes, which had a starburst morphology (arrows), were observed in both the control (A) and zi/zi (B). C, D, High-power photomicrographs of each promyelinating oligodendrocytes, respectively. The zi/zi promyelinating oligodendrocyte (D) exhibited an oval cell body with multiple filopodia and a profuse network of processes, similar to those of wild-type (C). E, F, Reticular formation of pons. There were many Rip-positive myelinating oligodendrocytes ensheathing longitudinal axon bundles. G, H, High-power photomicrographs of the myelinating oligodendrocyte in the control (G) or zi/zi (H). Each myelinating oligodendrocyte had the multiple linear processes arrays connected to the cell body by primary processes (arrows), indicating that they had commenced axonal ensheathment. Scale bars: 100 μm (A, B); 20 μm (C, D); 100 μm (E, F); 20 μm (G, H).

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BMC Neuroscience

ISSN: 1471-2202

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