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Figure 9 | BMC Neuroscience

Figure 9

From: Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir

Figure 9

NFV-induced changes in Notch 4 processing are independent of GSK3-β phosphorylation levels. Western analyses of A) CEC exposed to NFV for varying lengths of time. Phosphorylated GSK3-β (dark bars) (*p ≤ 0.02) and total GSK3-β (lighter bars) (*p ≤ 0.002), B) phospho- and total GSK3-β in NFV-treated CEC in the presence of Vitamin E (VE) or the PI3K inhibitor, LY29004 (LY) and C) Total and Processed Notch 4 in NFV-treated CEC in the presence of Vitamin E (VE) or the PI3K inhibitor, LY29004 (LY), *p ≤ 0.05 by one way ANOVA with Dunnett's post hoc test when compared to untreated control. Graphs reflect results from three separate experiments.

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