TY - JOUR AU - Banks, W. A. AU - Ercal, N. AU - Price, T. O. PY - 2006 DA - 2006// TI - The blood-brain barrier in neuroAIDS JO - Current HIV Research VL - 4 ID - Banks2006 ER - TY - JOUR AU - Dallasta, L. M. AU - Pisarov, L. A. AU - Esplen, J. E. AU - Werley, J. V. AU - Moses, A. V. AU - Nelson, J. A. AU - Achim, C. L. PY - 1999 DA - 1999// TI - Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis JO - The American Journal of Pathology VL - 155 ID - Dallasta1999 ER - TY - JOUR AU - Toborek, M. AU - Lee, Y. W. AU - Flora, G. AU - Pu, H. AU - Andras, I. E. AU - Wylegala, E. AU - Hennig, B. AU - Nath, A. PY - 2005 DA - 2005// TI - Mechanisms of the blood-brain barrier disruption in HIV-1 infection JO - Cellular and Molecular Neurobiology VL - 25 ID - Toborek2005 ER - TY - JOUR AU - Wang, X. AU - Chai, H. AU - Yao, Q. AU - Chen, C. PY - 2007 DA - 2007// TI - Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction JO - Journal of Acquired Immune Deficiency Syndromes VL - 44 ID - Wang2007 ER - TY - JOUR AU - Mondal, D. AU - Pradhan, L. AU - Ali, M. AU - Agrawal, K. C. PY - 2004 DA - 2004// TI - HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants JO - Cardiovascular Toxicology VL - 4 ID - Mondal2004 ER - TY - JOUR AU - Sgadari, C. AU - Barillari, G. AU - Toschi, E. AU - Carlei, D. AU - Bacigalupo, I. AU - Baccarini, S. AU - Palladino, C. AU - Leone, P. AU - Bugarini, R. AU - Malavasi, L. PY - 2002 DA - 2002// TI - HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma JO - Nature medicine VL - 8 ID - Sgadari2002 ER - TY - JOUR AU - Curry, C. L. AU - Reed, L. L. AU - Golde, T. E. AU - Miele, L. AU - Nickoloff, B. J. AU - Foreman, K. E. PY - 2005 DA - 2005// TI - Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells JO - Oncogene VL - 24 ID - Curry2005 ER - TY - JOUR AU - Ikezoe, T. AU - Saito, T. AU - Bandobashi, K. AU - Yang, Y. AU - Koeffler, H. P. AU - Taguchi, H. PY - 2004 DA - 2004// TI - HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2 JO - Molecular Cancer Therapeutics VL - 3 ID - Ikezoe2004 ER - TY - JOUR AU - Yang, Y. AU - Ikezoe, T. AU - Takeuchi, T. AU - Adachi, Y. AU - Ohtsuki, Y. AU - Takeuchi, S. AU - Koeffler, H. P. AU - Taguchi, H. PY - 2005 DA - 2005// TI - HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling JO - Cancer Science VL - 96 ID - Yang2005 ER - TY - JOUR AU - Taylor, K. L. AU - Henderson, A. M. AU - Hughes, C. C. PY - 2002 DA - 2002// TI - Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression JO - Microvascular Research VL - 64 ID - Taylor2002 ER - TY - JOUR AU - Liu, Z. J. AU - Shirakawa, T. AU - Li, Y. AU - Soma, A. AU - Oka, M. AU - Dotto, G. P. AU - Fairman, R. M. AU - Velazquez, O. C. AU - Herlyn, M. PY - 2003 DA - 2003// TI - Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis JO - Molecular and Cellular Biology VL - 23 ID - Liu2003 ER - TY - JOUR AU - Baron, M. PY - 2003 DA - 2003// TI - An overview of the Notch signalling pathway JO - Seminars in Cell & Developmental Biology VL - 14 ID - Baron2003 ER - TY - JOUR AU - Shirayoshi, Y. AU - Yuasa, Y. AU - Suzuki, T. AU - Sugaya, K. AU - Kawase, E. AU - Ikemura, T. AU - Nakatsuji, N. PY - 1997 DA - 1997// TI - Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis JO - Genes Cells VL - 2 ID - Shirayoshi1997 ER - TY - JOUR AU - Leong, K. G. AU - Hu, X. AU - Li, L. AU - Noseda, M. AU - Larrivee, B. AU - Hull, C. AU - Hood, L. AU - Wong, F. AU - Karsan, A. PY - 2002 DA - 2002// TI - Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation JO - Molecular and Cellular Biology VL - 22 ID - Leong2002 ER - TY - JOUR AU - Matsumoto, T. AU - Turesson, I. AU - Book, M. AU - Gerwins, P. AU - Claesson-Welsh, L. PY - 2002 DA - 2002// TI - p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis JO - The Journal of Cell Biology VL - 156 ID - Matsumoto2002 ER - TY - JOUR AU - Espinosa, L. AU - Ingles-Esteve, J. AU - Aguilera, C. AU - Bigas, A. PY - 2003 DA - 2003// TI - Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways JO - The Journal of Biological Chemistry VL - 278 ID - Espinosa2003 ER - TY - JOUR AU - Foltz, D. R. AU - Nye, J. S. PY - 2001 DA - 2001// TI - Hyperphosphorylation and association with RBP of the intracellular domain of Notch1 JO - Biochemical and Biophysical Research Communications VL - 286 ID - Foltz2001 ER - TY - JOUR AU - Foltz, D. R. AU - Santiago, M. C. AU - Berechid, B. E. AU - Nye, J. S. PY - 2002 DA - 2002// TI - Glycogen synthase kinase-3beta modulates notch signaling and stability JO - Curr Biol VL - 12 ID - Foltz2002 ER - TY - JOUR AU - Barry, M. AU - Gibbons, S. AU - Back, D. AU - Mulcahy, F. PY - 1997 DA - 1997// TI - Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations JO - Clinical pharmacokinetics VL - 32 ID - Barry1997 ER - TY - JOUR AU - Li, H. L. AU - Roch, J. M. AU - Sundsmo, M. AU - Otero, D. AU - Sisodia, S. AU - Thomas, R. AU - Saitoh, T. PY - 1997 DA - 1997// TI - Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease JO - Journal of neurobiology VL - 32 ID - Li1997 ER - TY - JOUR AU - Shawber, C. J. AU - Kitajewski, J. PY - 2004 DA - 2004// TI - Notch function in the vasculature: insights from zebrafish, mouse and man JO - Bioessays VL - 26 ID - Shawber2004 ER - TY - JOUR AU - McKenzie, G. AU - Ward, G. AU - Stallwood, Y. AU - Briend, E. AU - Papadia, S. AU - Lennard, A. AU - Turner, M. AU - Champion, B. AU - Hardingham, G. E. PY - 2006 DA - 2006// TI - Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals JO - BMC cell biology VL - 7 ID - McKenzie2006 ER - TY - JOUR AU - Ruel, L. AU - Bourouis, M. AU - Heitzler, P. AU - Pantesco, V. AU - Simpson, P. PY - 1993 DA - 1993// TI - Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch JO - Nature VL - 362 ID - Ruel1993 ER - TY - JOUR AU - De Barros, S. AU - Zakaroff-Girard, A. AU - Lafontan, M. AU - Galitzky, J. AU - Bourlier, V. PY - 2007 DA - 2007// TI - Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9 JO - The Journal of pharmacology and experimental therapeutics VL - 320 ID - De Barros2007 ER - TY - JOUR AU - Tovo, P. A. PY - 2000 DA - 2000// TI - Highly active antiretroviral therapy inhibits cytokine production in HIV-uninfected subjects JO - AIDS VL - 14 ID - Tovo2000 ER - TY - JOUR AU - Gruber, A. AU - Wheat, J. C. AU - Kuhen, K. L. AU - Looney, D. J. AU - Wong-Staal, F. PY - 2001 DA - 2001// TI - Differential effects of HIV-1 protease inhibitors on dendritic cell immunophenotype and function JO - The Journal of Biological Chemistry VL - 276 ID - Gruber2001 ER - TY - JOUR AU - Barillari, G. AU - Sgadari, C. AU - Toschi, E. AU - Monini, P. AU - Ensoli, B. PY - 2003 DA - 2003// TI - HIV protease inhibitors as new treatment options for Kaposi's sarcoma JO - Drug Resist Updat VL - 6 ID - Barillari2003 ER - TY - JOUR AU - Kim, S. H. AU - Yin, Y. I. AU - Li, Y. M. AU - Sisodia, S. S. PY - 2004 DA - 2004// TI - Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway JO - The Journal of Biological Chemistry VL - 279 ID - Kim2004 ER - TY - JOUR AU - Pouyssegur, J. AU - Mechta-Grigoriou, F. PY - 2006 DA - 2006// TI - Redox regulation of the hypoxia-inducible factor JO - Biological Chemistry VL - 387 ID - Pouyssegur2006 ER - TY - JOUR AU - Pore, N. AU - Gupta, A. K. AU - Cerniglia, G. J. AU - Jiang, Z. AU - Bernhard, E. J. AU - Evans, S. M. AU - Koch, C. J. AU - Hahn, S. M. AU - Maity, A. PY - 2006 DA - 2006// TI - Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy JO - Cancer Research VL - 66 ID - Pore2006 ER - TY - JOUR AU - Pore, N. AU - Gupta, A. K. AU - Cerniglia, G. J. AU - Maity, A. PY - 2006 DA - 2006// TI - HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells JO - Neoplasia VL - 8 ID - Pore2006 ER - TY - JOUR AU - Gupta, A. K. AU - Cerniglia, G. J. AU - Mick, R. AU - McKenna, W. G. AU - Muschel, R. J. PY - 2005 DA - 2005// TI - HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo JO - Cancer Research VL - 65 ID - Gupta2005 ER - TY - JOUR AU - Mottet, D. AU - Dumont, V. AU - Deccache, Y. AU - Demazy, C. AU - Ninane, N. AU - Raes, M. AU - Michiels, C. PY - 2003 DA - 2003// TI - Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells JO - The Journal of Biological Chemistry VL - 278 ID - Mottet2003 ER - TY - JOUR AU - Kopan, R. PY - 2002 DA - 2002// TI - Notch: a membrane-bound transcription factor JO - Journal of Cell Science VL - 115 ID - Kopan2002 ER - TY - JOUR AU - Vekrellis, K. AU - Ye, Z. AU - Qiu, W. Q. AU - Walsh, D. AU - Hartley, D. AU - Chesneau, V. AU - Rosner, M. R. AU - Selkoe, D. J. PY - 2000 DA - 2000// TI - Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme JO - J Neurosci VL - 20 ID - Vekrellis2000 ER - TY - JOUR AU - Schutt, M. AU - Zhou, J. AU - Meier, M. AU - Klein, H. H. PY - 2004 DA - 2004// TI - Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells JO - The Journal of Endocrinology VL - 183 ID - Schutt2004 ER - TY - JOUR AU - Bachmeier, C. J. AU - Spitzenberger, T. J. AU - Elmquist, W. F. AU - Miller, D. W. PY - 2005 DA - 2005// TI - Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier JO - Pharmaceutical Research VL - 22 ID - Bachmeier2005 ER - TY - JOUR AU - Perloff, M. D. AU - von Moltke, L. L. AU - Fahey, J. M. AU - Greenblatt, D. J. PY - 2007 DA - 2007// TI - Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells JO - The Journal of Pharmacy and Pharmacology VL - 59 ID - Perloff2007 ER - TY - JOUR AU - Storch, C. H. AU - Theile, D. AU - Lindenmaier, H. AU - Haefeli, W. E. AU - Weiss, J. PY - 2007 DA - 2007// TI - Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein JO - Biochemical Pharmacology VL - 73 ID - Storch2007 ER - TY - JOUR AU - Johnstone, R. W. AU - Ruefli, A. A. AU - Smyth, M. J. PY - 2000 DA - 2000// TI - Multiple physiological functions for multidrug transporter P-glycoprotein? JO - Trends in Biochemical Sciences VL - 25 ID - Johnstone2000 ER - TY - JOUR AU - Molla, A. AU - Vasavanonda, S. AU - Kumar, G. AU - Sham, H. L. AU - Johnson, M. AU - Grabowski, B. AU - Denissen, J. F. AU - Kohlbrenner, W. AU - Plattner, J. J. AU - Leonard, J. M. PY - 1998 DA - 1998// TI - Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus JO - Virology VL - 250 ID - Molla1998 ER - TY - JOUR AU - Kramer, H. PY - 2001 DA - 2001// TI - Neuralized: regulating notch by putting away delta JO - Developmental Cell VL - 1 ID - Kramer2001 ER - TY - JOUR AU - Carroll, K. D. AU - Bu, W. AU - Palmeri, D. AU - Spadavecchia, S. AU - Lynch, S. J. AU - Marras, S. A. AU - Tyagi, S. AU - Lukac, D. M. PY - 2006 DA - 2006// TI - Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway JO - Journal of Virology VL - 80 ID - Carroll2006 ER - TY - JOUR AU - Shankar, S. S. AU - Dube, M. P. PY - 2004 DA - 2004// TI - Clinical aspects of endothelial dysfunction associated with human immunodeficiency virus infection and antiretroviral agents JO - Cardiovascular toxicology VL - 4 ID - Shankar2004 ER - TY - JOUR AU - Navarra, T. AU - Del Turco, S. AU - Papa, A. AU - Battaglia, D. AU - Lazzerini, G. AU - Basta, G. PY - 2006 DA - 2006// TI - Lack of effect of alpha-tocopherol on in vitro angiogenesis JO - Microvascular Research VL - 72 ID - Navarra2006 ER - TY - JOUR AU - Capaldini, L. PY - 1997 DA - 1997// TI - Protease inhibitors' metabolic side effects: cholesterol, triglycerides, blood sugar, and "Crix belly." Interview with Lisa Capaldini, M.D. Interview by John S. James JO - AIDS treatment news VL - 277 ID - Capaldini1997 ER - TY - JOUR AU - Vagnucci, A. H. AU - Li, W. W. PY - 2003 DA - 2003// TI - Alzheimer's disease and angiogenesis JO - Lancet VL - 361 ID - Vagnucci2003 ER - TY - JOUR AU - Kogure, K. AU - Kato, H. PY - 1993 DA - 1993// TI - Altered gene expression in cerebral ischemia JO - Stroke; A Journal of Cerebral Circulation VL - 24 ID - Kogure1993 ER - TY - JOUR AU - Jogi, A. AU - Ora, I. AU - Nilsson, H. AU - Lindeheim, A. AU - Makino, Y. AU - Poellinger, L. AU - Axelson, H. AU - Pahlman, S. PY - 2002 DA - 2002// TI - Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype JO - Proceedings of the National Academy of Sciences of the United States of America VL - 99 ID - Jogi2002 ER -