Effect of the 5-HT
antagonist tropisetron on neurological deficits scores (A) and mortality rate (B) after pMCAO. Animals received a single i.p. injection of tropisetron or the vehicle 30 min before being subjected to pMCAO. Twenty-four hours later, neurological scores were evaluated following a 6-point scale as detailed in Materials and Methods. Median neurological score is marked in Panel A by a small horizontal bar. Mortality rate is presented as percentage (%). *p < 0.05 with respect to vehicle-treated animals.