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Figure 7 | BMC Neuroscience

Figure 7

From: Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

Figure 7

Inhibition of Aβ production by APP-TM peptides in cells stably overexpressing APP. HEK293 cells stably expressing Swedish mutant APP and the γ-secretase components were incubated overnight with APP-TM peptides. An Aβ ELISA immunoassay was used to quantify the concentration of Aβ40 (A) and Aβ42 (B) produced and secreted into the conditioned cell culture media. The effect of the APP-TM peptides on Aβ42/40 ratio is shown in C.

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BMC Neuroscience

ISSN: 1471-2202

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