Figure 6From: Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutantsComparison to the clinical pathology of AD patients. The dimerization constants of the APP-TM peptides were compared to the A) Aβ42/Aβ40 ratio and B) mean age of onset. The mean age of onset was obtained from all available families [2]. The dissociation constants are positively correlated to the Aβ42/Aβ40 ratios and similarly association constants are equally correlated to the mean age of onset.Back to article page