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Figure 2 | BMC Neuroscience

Figure 2

From: Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology

Figure 2

hES-NEP cells express functional LPA and S1P receptors coupled to PLC. (A) hES-NEP cells were treated with each of the indicated drugs at 10 μM, except for LPA which was assessed at 1 μM, for 30 minutes and assayed for IP levels as described in Methods. Results are reported as percent of basal inositol phosphate accumulation (CPM) with counts for drug treated wells divided by data from vehicle treated wells. (B) hES-NEP cells were treated with various concentrations of LPA in the presence (star) or absence (square) of Ptx for 30' and assayed for IP production. (C) hES-NEP cells were treated with various concentrations of S1P in the presence (star) or absence (square) of Ptx for 30' and assayed for IP production. Data are consistent with three independent experiments.

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