From: Imaging the neural circuitry and chemical control of aggressive motivation
 | Volume of Activation | % Change in BOLD Signal | ||
---|---|---|---|---|
Brain Area | Mate/Intruder SRX251 | Mate/Intruder Fluoxetine | Mate/Intruder SRX251 | Mate/Intruder Fluoxetine |
retrosplenial cortex (130) | 12 (1, 47) | 24 (9, 51)** | 5.2 ± 0.3 | 10.4 ± 0.4 |
orbital cortex (45) | 3 (0, 11) | 5 (0, 6) | 3.3 ± 0.2 | 2.0 ± 0.2 |
auditory cortex (98) | 11 (0, 33) | 13 (4, 38) | 4.0 ± 1.7 | 4.3 ± 0.5 |
somatosensory cortex (599) | 51 (1, 132) | 117 (37, 233)** | 3.8 ± 0.1 | 5.9 ± 0.4 |
motor cortex (386) | 24 (0, 71) | 57 (20, 181)** | 3.7 ± 0.2 | 5.6 ± 0.2 |
visual cortex (212) | 30 (3, 74) | 38 (8, 101) | 5.4 ± 0.5 | 7.6 ± 0.9 |
insular cortex (128) | 4 (0, 14) | 10 (4, 30)* | 3.1 ± 0.2 | 3.4 ± 0.4 |
prelimbic cortex (32) | 3 (0, 4) | 5 (1, 11) | 2.8 ± 0.1 | 2.5 ± 0.2 |
infralimbic cortex (17) | 0 (0, 3) | 5 (0, 9)** | 2.0 ± 0.1 | 1.6 ± 0.1 |
anterior cingulate ctx (73) | 6 (0, 15) | 13 (1, 32)** | 3.2 ± 0.1 | 3.6 ± 0.3 |
CA1 hippocampus (154) | 10 (0, 44) | 17 (2, 63) | 2.9 ± 0.3 | 3.3 ± 0.2 |
dentate gyrus (100) | 9 (0, 27) | 9 (0, 44) | 2.8 ± 0.3 | 3.0 ± 0.3 |
cortical n. amygdala (69) | 6 (0, 24) | 9 (3, 20) | 3.3 ± 0.2 | 4.6 ± 0.4 |
basal n. amygdala (24) | 1 (0, 3) | 3 (0, 5) | 2.3 ± 0.4 | 2.5 ± 0.2 |
central n. amygdala (13) | 0 (0, 1) | 0 (0, 2) | 1.0 ± 0.1 | 0.9 ± 0.1 |
medial n. amygdala (14) | 1 (0, 3) | 2 (0, 7) | 1.5 ± 0.4 | 2.7 ± 0.3 |
bed n. stria terminalis (15) | 0 (0, 3) | 3 (0, 7) | 2.5 ± 0.2 | 2.7 ± 0.2 |
lateral post. n. thalamus (18) | 1 (0, 5) | 1 (0, 6) | 1.9 ± 0.2 | 1.5 ± 0.1 |
anterior n. thalamus (12) | 0 (0, 3) | 1 (0, 4 | 1.0 ± 0.1 | 2.0 ± 0.3 |
substantia nigra (28) | 1 (0, 6) | 5 (0, 6)* | 2.6 ± 0.1 | 3.7 ± 0.3 |
ventral tegmentum (16) | 0 (0, 4) | 2 (0, 5) | 0.8 ± 0.2 | 1.8 ± 0.2 |
dorsal striatum (305) | 12 (0, 39) | 36 (5, 147)** | 2.5 ± 0.2 | 2.2 ± 0.2 |
ventral pallidum (41) | 1 (0, 5) | 3 (0, 6)* | 1.3 ± 0.2 | 2.0 ± 0.1 |
lateral hypothalamus (64) | 5 (0,15) | 8 (3, 15) | 2.9 ± 0.3 | 3.3 ± 0.3 |
periaquedutcal gray (42) | 4 (0, 15) | 3 (0, 7) | 1.9 ± 0.2 | 3.5 ± 0.6 |
raphe nuclei (15) | 1 (0, 6) | 1 (0, 2) | 2.1 ± 0.4 | 0.8 ± 0.1 |
accumbens (45) | 2 (0, 5) | 8 (0, 25)** | 2.8 ± 0.4 | 3.0 ± 0.2 |
PVN hypothalamus (3) | 1 (0,2) | 0 (0, 2) | 1.8 ± 0.1 | 2.0 ± 0.1 |