Figure 1

Three dimensional representations of BOLD activation. The pictures show translucent shells of the brain viewed from a caudal/dorsal perspective. The red depicts the localization of activated voxels interpolated into a 3D volume of activation for four experimental conditions: mate alone, mate/intruder, and pretreatment with SRX251 or fluoxetine, followed by the aggressive promoting stimulus of mate/intruder. The volumes of activation for each experimental condition are composed of 10 male residents each. Once fully registered and segmented, the statistical responses for each animal are averaged on a voxel-by-voxel bases. Those averaged voxels that are significantly different from baseline and exceed a 2.0% threshold are show in their appropriate spatial location. The volumetric data shown in the whole brain 3D models on the left column were parsed into the four major brain areas noted. The geometric volumes constituting each major area like the hippocampus, i.e., subiculum, dentate gyrus, CA1, CA2, CA3 have been melded into a single volume shown in yellow.