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Table 2 Comparison of burst properties during MK-801 exposure in experiments measuring NMDA receptor-mediated EPSCs (EPSC) and those measuring whole cell current responses to bath NMDA after EPSC blockade (Extrasynaptic).

From: A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

Experiment Type

 

EPSC

Extrasynaptic

n

 

5

19

incubation time

min

4.5 ± 0.7

4.9 ± 0.5

number of bursts

 

6.6 ± 1.4

6.2 ± 1.2

number of spikes

 

106 ± 34

97 ± 13

RMP

mV

-60.9 ± 4.7

-58.2 ± 1.7

Vm during bursts

mV

-50.0 ± 2.0

-53.7 ± 2.0

depolarisation

V.s

202.4 ± 73.6

187.6 ± 34.6

  1. Average membrane potential (Vm) during bursts was calculated from the burst onset till the return to the baseline resting membrane potential (RMP). Depolarization was calculated from the integral of the membrane potential above RMP over this same period summed across all bursts for each cell.
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BMC Neuroscience

ISSN: 1471-2202

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