Behavioral performance in the water maze of APP tg mice that received bilateral injections of LV-NEP into the neocortex and hippocampus. (A) Test with the visible and submerged platform. *Significant difference on individual days between LV-NEP treated APP tg mice and LV-NEPX or LV-empty treated APP tg mice. **Significant difference for the sum/average of days 4–7 between LV-NEP treated APP tg mice and LV-NEPX or LV-empty treated APP tg mice (p < 0.05 two way ANOVA). (B) Probe test. Mice treated with LV-NEP showed improved behavioral performance compared to LV-empty and LV-NEPX. * = p < 0.05 one way ANOVA when compared to LV-NEP treated APP tg mice or Nontg mice (n = 8 mice per group, F = 4.987, DF = 3, p = 0.0041).