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Figure 4 | BMC Neuroscience

Figure 4

From: Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

Figure 4

Double immunolabelling analysis of intracellular Aβ immunoreactivity in the brains of APP tg mice. (A-C) Images of intracellular APP and Aβ immunoreactivity obtained in the neocortex with sections immunostained with an antibody against Aβ (4G8) (red) and APP (8E5)(green) from the brains of APP tg mice (12 m/o). (D-F) Images of intracellular APP and Aβ immunoreactivity in sections immunostained with an antibody against Aβ (82E1) (red) and APP (8E5)(green). Co-localization of the Aβ and APP staining is identified with a white arrow. Cells staining for APP alone are denoted with a yellow arrow, and cells staining for Aβ alone are denoted with a asterisk. Bar is (A-C) 10 μm, (D-F) 5 μm.

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