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Table 2 Food intake of 17-h fasted mice during first 30 min measured (maximal effect) in Experiment 1 and 2

From: Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice

Compound/dose

   

Food intake/30 min

(g ± SEM)

i.p.

 

i.c.v.

  

saline

   

0.77 ± 0.06

  

saline

 

0.73 ± 0.07

CCK-8

0.4 μg/kg

  

0.80 ± 0.13

 

4

  

0.60 ± 0.09

  

CART

0.1 μg/mouse

0.54 ± 0.04 **

   

0.5

0.40 ± 0.07 ***

CCK-8

0.4 μg/kg

CART

0.1 μg/mouse

0.45 ± 0.13 **

 

4

 

0.1

0.24 ± 0.03 *** +

CCK-8

0.4 μg/kg

CART

0.5 μg/mouse

0.22 ± 0.02 ***

 

4

 

0.5

0.08 ± 0.01 *** ++

devazepide

1 mg/kg

  

0.93 ± 0.05

 

1

CART

0.1 μg/mouse

0.65 ± 0.11

 

1

 

0.5

0.69 ± 0.08

L365,260

1

  

0.79 ± 0.05

 

1

 

0.5

0.34 ± 0.01 ***

  1. **P < 0.01, ***P < 0.001 versus saline-treated group. +P < 0.05 versus group treated by CART, 0.1 μg/mouse, ++ P < 0.01 versus group treated by CART, 0.5 μg/mouse.
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BMC Neuroscience

ISSN: 1471-2202

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