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Table 3 Enriched categories – genes significantly up- or down-regulated at 8 months (but not significant at 3 or 5 months)

From: Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response

Enriched Category (p-value) Subcategory Examples 3 mo 5 mo 8 mo
    (-fold change)
Purine Nucleotide (p < 0.00025) Kinases av-yes homolog -1.1 1.5 2.7
   CaM kinase-4 1.2 -1.1 2.5
   B-Raf 1.1 1.1 2.3
   DAP-kinase 1 -1.2 1.3 2.1
   bUhm Kinase 1 1.0 -1.3 -2.5
  GTPases RhoC 1.3 1.5 2.4
   Era1 1.8 -1.1 2.3
   aGimap4 2.2 1.1 2.3
  Receptors EDG3 1.9 2.2 2.5
   bEphRa3 1.7 -1.0 -2.7
  Transporters aABC1 1.7 1.9 2.3
   bABCA8a -1.6 -1.2 -2.1
  Kinesins Kinesin 18a -1.2 1.7 2.1
   bKinesin 5a/c 1.0 -1.3 -2.0
Negative Regulators Of Cellular Processes (p < 0.0037) Transcription Factors a,bC/EBP-β 1.3 1.4 2.6
   a,bC/EBP-α 1.1 1.4 2.2
   aKruppel-like 4 1.3 1.8 2.1
   Midline -1.9 -1.5 -2.2
   bHes5 1.2 -1.1 -3.3
  Growth Factors aIGF-1 1.6 1.6 3.2
   a,bCNTF 1.4 1.5 2.8
  Signaling aRGS-1 1.2 2.0 5.0
   RGS-2 1.2 1.0 2.2
   bAA 8 lipoxygenase -1.5 -1.1 -2.2
Intracellular Transport (p < 0.013) Proton/Solute Carriers a,bUCP2 -1.8 -1.0 3.2
   Slc1a3 (glial) -1.3 1.2 2.6
  Nuclear Transport Nucleoporin214 -1.0 1.1 2.6
   Ipoll -1.0 -1.0 2.4
Positive Regulators Of Cellular Processes (p < 0.018) Transcription Factors bAtonal homolog-1 -2.0 1.3 -2.4
   aNFAT5 1.2 1.1 -2.8
Cell Adhesion (p < 0.018) Cell surface aICAM 1.8 2.5 5.4
   aCD44 1.2 2.4 4.5
   Annexin A9 1.7 1.2 3.0
  Extracellular matrix Procollagen ivα5 1.2 1.7 2.9
   Transglutaminase 2c 1.4 1.6 2.2
  1. aReported to be highly expressed in immune cells
  2. bReported to be highly expressed in neuronal cells