Table 3 Enriched categories – genes significantly up- or down-regulated at 8 months (but not significant at 3 or 5 months)
Enriched Category (p-value) | Subcategory | Examples | 3 mo | 5 mo | 8 mo |
|---|---|---|---|---|---|
| Â | Â | Â | (-fold change) | ||
Purine Nucleotide (p < 0.00025) | Kinases | av-yes homolog | -1.1 | 1.5 | 2.7 |
| Â | Â | CaM kinase-4 | 1.2 | -1.1 | 2.5 |
| Â | Â | B-Raf | 1.1 | 1.1 | 2.3 |
| Â | Â | DAP-kinase 1 | -1.2 | 1.3 | 2.1 |
| Â | Â | bUhm Kinase 1 | 1.0 | -1.3 | -2.5 |
| Â | GTPases | RhoC | 1.3 | 1.5 | 2.4 |
| Â | Â | Era1 | 1.8 | -1.1 | 2.3 |
| Â | Â | aGimap4 | 2.2 | 1.1 | 2.3 |
| Â | Receptors | EDG3 | 1.9 | 2.2 | 2.5 |
| Â | Â | bEphRa3 | 1.7 | -1.0 | -2.7 |
| Â | Transporters | aABC1 | 1.7 | 1.9 | 2.3 |
| Â | Â | bABCA8a | -1.6 | -1.2 | -2.1 |
| Â | Kinesins | Kinesin 18a | -1.2 | 1.7 | 2.1 |
| Â | Â | bKinesin 5a/c | 1.0 | -1.3 | -2.0 |
Negative Regulators Of Cellular Processes (p < 0.0037) | Transcription Factors | a,bC/EBP-β | 1.3 | 1.4 | 2.6 |
|  |  | a,bC/EBP-α | 1.1 | 1.4 | 2.2 |
| Â | Â | aKruppel-like 4 | 1.3 | 1.8 | 2.1 |
| Â | Â | Midline | -1.9 | -1.5 | -2.2 |
| Â | Â | bHes5 | 1.2 | -1.1 | -3.3 |
| Â | Growth Factors | aIGF-1 | 1.6 | 1.6 | 3.2 |
| Â | Â | a,bCNTF | 1.4 | 1.5 | 2.8 |
| Â | Signaling | aRGS-1 | 1.2 | 2.0 | 5.0 |
| Â | Â | RGS-2 | 1.2 | 1.0 | 2.2 |
| Â | Â | bAA 8 lipoxygenase | -1.5 | -1.1 | -2.2 |
Intracellular Transport (p < 0.013) | Proton/Solute Carriers | a,bUCP2 | -1.8 | -1.0 | 3.2 |
| Â | Â | Slc1a3 (glial) | -1.3 | 1.2 | 2.6 |
| Â | Nuclear Transport | Nucleoporin214 | -1.0 | 1.1 | 2.6 |
| Â | Â | Ipoll | -1.0 | -1.0 | 2.4 |
Positive Regulators Of Cellular Processes (p < 0.018) | Transcription Factors | bAtonal homolog-1 | -2.0 | 1.3 | -2.4 |
| Â | Â | aNFAT5 | 1.2 | 1.1 | -2.8 |
Cell Adhesion (p < 0.018) | Cell surface | aICAM | 1.8 | 2.5 | 5.4 |
| Â | Â | aCD44 | 1.2 | 2.4 | 4.5 |
| Â | Â | Annexin A9 | 1.7 | 1.2 | 3.0 |
|  | Extracellular matrix | Procollagen ivα5 | 1.2 | 1.7 | 2.9 |
| Â | Â | Transglutaminase 2c | 1.4 | 1.6 | 2.2 |