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Table 2 Enriched categories – genes significantly up- or down-regulated at 5 months

From: Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response

Enriched Category (p-value)

Subcategory

Examples

3 mo

5 mo

8 mo

   

(-fold change)

Immune Response (p < 6.8 × 10-28)

Complement

aC4b

4.8

10.1

8.6

 

components

aC3

1.2

6.5

14.7

  

C1q

2.3

2.6

3.2

 

Chemotaxis

aCXCL21

11.4

9.9

6.9

  

aCXCL10

7.5

8.3

6.7

  

aCXCL12

3.4

7.4

4.4

  

aCXCL5

2.3

6.1

2.3

  

aCXCL3

2.4

3.8

2.8

  

dCXCL6

2.9

2.8

1.8

  

aIntegrin β2

1.6

3.3

4.6

  

aIntegrin αx

2.3

3.8

5.2

 

Phagocytosis

aClec7a

10.3

13.6

14.7

 

Immunoglobulin

aFc receptor, IgG

2.7

4.5

6.9

 

Receptors

    
 

Protease inhibitors

a,bSerpin3An

4.3

13.8

20.3

  

aCystatin F

5.3

12.0

13.6

  

α2-macroglobulin

1.3

3.1

5.0

  

TIMP

1.5

2.9

6.9

Lysosome (p < 0.0034)

Cathepsins

aCathepsin S

2.1

2.4

2.7

  

a,dCathepsin Z

1.7

2.3

2.3

  

aCathepsin D

1.5

2.1

2.7

Water Transport (p < 0.017)

Aquaporins and related

c,dAquaporin 4

1.5

2.5

2.4

  

Podoplanin

1.6

2.8

2.8

  1. aReported to be highly expressed in immune cells
  2. bReported to be highly expressed in neuronal cells
  3. cReported to be highly expressed in astrocytes
  4. dResults from one probe set from two or more showing similar results