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Table 2 Enriched categories – genes significantly up- or down-regulated at 5 months

From: Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response

Enriched Category (p-value) Subcategory Examples 3 mo 5 mo 8 mo
    (-fold change)
Immune Response (p < 6.8 × 10-28) Complement aC4b 4.8 10.1 8.6
  components aC3 1.2 6.5 14.7
   C1q 2.3 2.6 3.2
  Chemotaxis aCXCL21 11.4 9.9 6.9
   aCXCL10 7.5 8.3 6.7
   aCXCL12 3.4 7.4 4.4
   aCXCL5 2.3 6.1 2.3
   aCXCL3 2.4 3.8 2.8
   dCXCL6 2.9 2.8 1.8
   aIntegrin β2 1.6 3.3 4.6
   aIntegrin αx 2.3 3.8 5.2
  Phagocytosis aClec7a 10.3 13.6 14.7
  Immunoglobulin aFc receptor, IgG 2.7 4.5 6.9
  Receptors     
  Protease inhibitors a,bSerpin3An 4.3 13.8 20.3
   aCystatin F 5.3 12.0 13.6
   α2-macroglobulin 1.3 3.1 5.0
   TIMP 1.5 2.9 6.9
Lysosome (p < 0.0034) Cathepsins aCathepsin S 2.1 2.4 2.7
   a,dCathepsin Z 1.7 2.3 2.3
   aCathepsin D 1.5 2.1 2.7
Water Transport (p < 0.017) Aquaporins and related c,dAquaporin 4 1.5 2.5 2.4
   Podoplanin 1.6 2.8 2.8
  1. aReported to be highly expressed in immune cells
  2. bReported to be highly expressed in neuronal cells
  3. cReported to be highly expressed in astrocytes
  4. dResults from one probe set from two or more showing similar results