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Table 1 Enriched categories – genes significantly up- or down-regulated at 3 months (but not significant at 5 or 8 months)

From: Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response

Enriched Category (p-value)

Subcategory

Examples

3 mo

5 mo

8 mo

   

(-fold change)

Pattern Specification (p < 0.0023)

Immediate early genes

aArc

3.5

2.7

1.0

  

aCysteine-rich protein 61

3.0

1.8

4.5

  

Zbtb16

-2.4

-1.3

1.8

Transcription (p < 0.015)

Immediate early genes

ac-Fos

2.9

3.6

2.4

  

btg2

2.7

1.2

1.1

  

aNR4A1

2.3

2.1

-1.1

  

aJun-b

1.7

1.9

1.5

Response to DNA Damage Stimulus (p < 0.021)

DNA replication and stress response

hmg2

2.0

1.3

2.2

  

PCNA

-1.8

1.1

1.1

  

Sgk1

-2.3

1.1

2.4

  1. aReported to be immediate-early response genes expressed in central nervous system