Table 1 Enriched categories – genes significantly up- or down-regulated at 3 months (but not significant at 5 or 8 months)
| Enriched Category (p-value) | Subcategory | Examples | 3 mo | 5 mo | 8 mo |
|---|---|---|---|---|---|
| (-fold change) | |||||
| Pattern Specification (p < 0.0023) | Immediate early genes | aArc | 3.5 | 2.7 | 1.0 |
| aCysteine-rich protein 61 | 3.0 | 1.8 | 4.5 | ||
| Zbtb16 | -2.4 | -1.3 | 1.8 | ||
| Transcription (p < 0.015) | Immediate early genes | ac-Fos | 2.9 | 3.6 | 2.4 |
| btg2 | 2.7 | 1.2 | 1.1 | ||
| aNR4A1 | 2.3 | 2.1 | -1.1 | ||
| aJun-b | 1.7 | 1.9 | 1.5 | ||
| Response to DNA Damage Stimulus (p < 0.021) | DNA replication and stress response | hmg2 | 2.0 | 1.3 | 2.2 |
| PCNA | -1.8 | 1.1 | 1.1 | ||
| Sgk1 | -2.3 | 1.1 | 2.4 | ||