A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion

Mitsios, Nick; Saka, Mohamad; Krupinski, Jerzy; Pennucci, Roberta; Sanfeliu, Coral; Wang, Qiuyu; Rubio, Francisco; Gaffney, John; Kumar, Pat; Kumar, Shant; Sullivan, Matthew; Slevin, Mark

doi:10.1186/1471-2202-8-93

Table 3 Genes deregulated in both human and animal stroke microarrays

From: A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion

	Human		Rat		Human		Rat
Gene name	GenBank	SwissProt	GenBank	SwissProt	Max/min	Days	Max/min	Time
c-jun proto-oncogene	J04111	P05412	X17163	P17325	4.4-fold	9 – 20	3.5-fold	1 h – 24 h
Matrix metalloproteinase 11	X57766	P24347	U46034	P97568	3.2-fold	2 – 20	2.6-fold	3 days
Calcium/calmodulin-dependent kinase (CAMK1)	L41816	Q14012	L24907	Q63450	17.2-fold	2 – 20	0.05-fold	21 days
			L26288	Q63084
LIM domain kinase 1	D26309	P53667	D31873	P53669	3.6-fold	2 – 20	2.4-fold	3 days
							0.4-fold	21 days
T-Lymphocyte maturation-associated protein	M15800	P21145	U31367	Q64349	1.7-fold	2 – 6	0.2-fold	21 days
Retinoic Acid Receptor beta	M84820	P28702	M81766	P49743	2.0-fold	2 – 6	0.1-fold	21 days
	S54072	P28703
Tyrosine Phosphatase 1B	M31724	P18031	M33962	P20417	3.4-fold	2 – 6	0.2-fold	21 days
Adenosine A1 Receptor	S56143	P30542	M64299	P25099	2.6-fold	2 – 6	5.2-fold	4 hrs
Growth arrest & DNA damage-inducible 153	S40706	P35638	U30186	Q62804	2.4-fold	2 – 6	2.1-fold	3 days
	S62138
Glutamate Decarboxylase 67	M81883	Q99259	M34445	P18088	5.6-fold	2 – 6	2.5-fold	21 days
Glutamate Decarboxylase 65	M81882	Q99259	M72422	Q05683	22.7-fold	2 – 20	2.2-fold	3 days
Neurotrophin 3	M37763	P20783	M34643	P18280	5.1-fold	2 – 37	2.2-fold	12 hrs
Inhibitor of DNA binding 2	M97796	Q02363	D10863	P41137	5.6-fold	2 – 20	0.4-fold	21 days
Neuropeptide Y	K01911	P01303	M20373	P07808	8.8-fold	2 – 20	0.04-fold	21 days
Glia Maturation Factor beta	M86492	P17774	Z11558	Q63228	7.6-fold	2 – 6	0.04-fold	21 days
High Mobility Group Protein 1	M23619	P17096	M64986	P27109	4.3-fold	2 – 37	3-fold	4 h – 3 d
				P27428			0.3-fold	21 days
Early Growth Response Protein 1	X52541	P18146	M18416	P08154	4.4-fold	2 – 20	3.9-fold	1 h – 12 h
	M62829		J04154				0.2-fold	21 days
TAT-Binding Protein 1	M34079	P17980	U77918	P97638	3.8-fold	2 – 20	0.4-fold	21 days
Glutathione S-Transferase 1	J03746	P10620	J03752	P08011	17.5-fold	2 – 20	10.8-fold	24 h – 21 d
Fibroblast Growth Factor Receptor 1	M63887	Q02063	D12498	Q04589	10.1-fold	2 – 20	4-fold	4 h – 24 h
	M63888	Q02065
	M63889
Interleukin 10	M57627	P22301	L02926	P29456	2.4-fold	2 – 20 26 – 37	6.4-fold	21 days
				Q63263	0.2-fold
Heat Shock Protein 27	X54079	P04792	M86389	P42930	0.6-fold	2 – 20	15.2-fold	4 h – 24 h
Heat Shock Protein 70	M11717	P08107	Z27118	Q63718	0.6-fold	2 – 6	9.4-fold	1 h – 24 h
		P19790
Thioredoxin Peroxidase 1	L19185	P32119	U06099	P35704	4.9-fold	2 – 20	3.9-fold	21 days
	X82321	P31945
Platelet-Derived Growth Factor A	X06374	P04085	L06894	P28576	1.6-fold	2 – 6	0.5-fold	21 days
Matrix Metalloproteinase 14	X83535	Q92678	X83537	Q10739	6.9-fold	2 – 6	3.3-fold	24 h – 3 d
Kinase receptor TYRO3 Sky proto-oncogene	D17517	Q06418	D37880	P55146	3.1-fold	9 – 20	4.0-fold	24 h – 3 d
							0.4-fold	21 days
CSF-1-Receptor	X03663	P07333	X61479	Q00495	89.2-fold	9 – 20	2.8-fold	3 days
Insulin-like Growth Factor Binding Protein 2	M35410	P18065	J04486	P12843	79.7-fold	9 – 20	2.1-fold	3 days
Mitogen activated kinase 1/2	M84489	P28482	M64300	P27703	48.6-fold	9 – 20	0.3-fold	21 days
Aquaporin 4	U34846	P55087	U14007	P47863	18-fold	9 – 20	3.2-fold	3 days
erbB2 proto-oncogene Neu proto-oncogene	M95667	P04626	X03362	P06494	11.2-fold	9 – 20	2.7-fold	12 hrs
	M11730	Q14256
L-type calcium channel β3	U07139	P54284	M88751	P54287	10.3-fold	9 – 20	8.6-fold	21 days
Ras-related protein RAB3A	M28210	P20336	X06889	P05713	13.9-fold	9 – 20	0.3-fold	21 days
CAMK-II beta	U50358	Q13554	M16112	P08413	1.8-fold	9 – 20	0.3-fold	21 days
Growth Factor Receptor-Bound 2	L29511	Q63057	D49846	Q63057	19.9-fold	9 – 20	2.7-fold	3 days
	M96995	Q14450		Q14450
Signal Transducer & Activator of Transcription 3	L29277	P40763	X91810	P52631	0.4-fold	9 – 20	6.6-fold	4 h – 3 d
							0.05-fold	21 days
Neuronatin	U25033	Q16517	U08290	Q62649	11.1-fold	9 – 20	0.4-fold	21 days
				Q62663
Glutathione S-Transferase P	X08058	P09211	X02904	P04906	3.1-fold	9 – 20	0.1-fold	1 hr
Glucocorticoid-regulated serine/threonine kinase GSK	AJ000512	O00141	L01624	Q06226	0.6-fold	26 – 37	2.4-fold	3 days
							0.05-fold	21 days
Glucose Transporter 1	K03195	P11166	M13979	P11167	0.6-fold	26 – 37	11.6-fold	4 h – 21 d

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