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Table 3 Genes deregulated in both human and animal stroke microarrays

From: A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion

  Human Rat Human Rat
Gene name GenBank SwissProt GenBank SwissProt Max/min Days Max/min Time
c-jun proto-oncogene J04111 P05412 X17163 P17325 4.4-fold 9 – 20 3.5-fold 1 h – 24 h
Matrix metalloproteinase 11 X57766 P24347 U46034 P97568 3.2-fold 2 – 20 2.6-fold 3 days
Calcium/calmodulin-dependent kinase (CAMK1) L41816 Q14012 L24907 Q63450 17.2-fold 2 – 20 0.05-fold 21 days
    L26288 Q63084     
LIM domain kinase 1 D26309 P53667 D31873 P53669 3.6-fold 2 – 20 2.4-fold 3 days
        0.4-fold 21 days
T-Lymphocyte maturation-associated protein M15800 P21145 U31367 Q64349 1.7-fold 2 – 6 0.2-fold 21 days
Retinoic Acid Receptor beta M84820 P28702 M81766 P49743 2.0-fold 2 – 6 0.1-fold 21 days
  S54072 P28703       
Tyrosine Phosphatase 1B M31724 P18031 M33962 P20417 3.4-fold 2 – 6 0.2-fold 21 days
Adenosine A1 Receptor S56143 P30542 M64299 P25099 2.6-fold 2 – 6 5.2-fold 4 hrs
Growth arrest & DNA damage-inducible 153 S40706 P35638 U30186 Q62804 2.4-fold 2 – 6 2.1-fold 3 days
  S62138        
Glutamate Decarboxylase 67 M81883 Q99259 M34445 P18088 5.6-fold 2 – 6 2.5-fold 21 days
Glutamate Decarboxylase 65 M81882 Q99259 M72422 Q05683 22.7-fold 2 – 20 2.2-fold 3 days
Neurotrophin 3 M37763 P20783 M34643 P18280 5.1-fold 2 – 37 2.2-fold 12 hrs
Inhibitor of DNA binding 2 M97796 Q02363 D10863 P41137 5.6-fold 2 – 20 0.4-fold 21 days
Neuropeptide Y K01911 P01303 M20373 P07808 8.8-fold 2 – 20 0.04-fold 21 days
Glia Maturation Factor beta M86492 P17774 Z11558 Q63228 7.6-fold 2 – 6 0.04-fold 21 days
High Mobility Group Protein 1 M23619 P17096 M64986 P27109 4.3-fold 2 – 37 3-fold 4 h – 3 d
     P27428    0.3-fold 21 days
Early Growth Response Protein 1 X52541 P18146 M18416 P08154 4.4-fold 2 – 20 3.9-fold 1 h – 12 h
  M62829   J04154     0.2-fold 21 days
TAT-Binding Protein 1 M34079 P17980 U77918 P97638 3.8-fold 2 – 20 0.4-fold 21 days
Glutathione S-Transferase 1 J03746 P10620 J03752 P08011 17.5-fold 2 – 20 10.8-fold 24 h – 21 d
Fibroblast Growth Factor Receptor 1 M63887 Q02063 D12498 Q04589 10.1-fold 2 – 20 4-fold 4 h – 24 h
  M63888 Q02065       
  M63889        
Interleukin 10 M57627 P22301 L02926 P29456 2.4-fold 2 – 20 26 – 37 6.4-fold 21 days
     Q63263 0.2-fold    
Heat Shock Protein 27 X54079 P04792 M86389 P42930 0.6-fold 2 – 20 15.2-fold 4 h – 24 h
Heat Shock Protein 70 M11717 P08107 Z27118 Q63718 0.6-fold 2 – 6 9.4-fold 1 h – 24 h
   P19790       
Thioredoxin Peroxidase 1 L19185 P32119 U06099 P35704 4.9-fold 2 – 20 3.9-fold 21 days
  X82321 P31945       
Platelet-Derived Growth Factor A X06374 P04085 L06894 P28576 1.6-fold 2 – 6 0.5-fold 21 days
Matrix Metalloproteinase 14 X83535 Q92678 X83537 Q10739 6.9-fold 2 – 6 3.3-fold 24 h – 3 d
Kinase receptor TYRO3 Sky proto-oncogene D17517 Q06418 D37880 P55146 3.1-fold 9 – 20 4.0-fold 24 h – 3 d
        0.4-fold 21 days
CSF-1-Receptor X03663 P07333 X61479 Q00495 89.2-fold 9 – 20 2.8-fold 3 days
Insulin-like Growth Factor Binding Protein 2 M35410 P18065 J04486 P12843 79.7-fold 9 – 20 2.1-fold 3 days
Mitogen activated kinase 1/2 M84489 P28482 M64300 P27703 48.6-fold 9 – 20 0.3-fold 21 days
Aquaporin 4 U34846 P55087 U14007 P47863 18-fold 9 – 20 3.2-fold 3 days
erbB2 proto-oncogene Neu proto-oncogene M95667 P04626 X03362 P06494 11.2-fold 9 – 20 2.7-fold 12 hrs
  M11730 Q14256       
L-type calcium channel β3 U07139 P54284 M88751 P54287 10.3-fold 9 – 20 8.6-fold 21 days
Ras-related protein RAB3A M28210 P20336 X06889 P05713 13.9-fold 9 – 20 0.3-fold 21 days
CAMK-II beta U50358 Q13554 M16112 P08413 1.8-fold 9 – 20 0.3-fold 21 days
Growth Factor Receptor-Bound 2 L29511 Q63057 D49846 Q63057 19.9-fold 9 – 20 2.7-fold 3 days
  M96995 Q14450   Q14450     
Signal Transducer & Activator of Transcription 3 L29277 P40763 X91810 P52631 0.4-fold 9 – 20 6.6-fold 4 h – 3 d
        0.05-fold 21 days
Neuronatin U25033 Q16517 U08290 Q62649 11.1-fold 9 – 20 0.4-fold 21 days
     Q62663     
Glutathione S-Transferase P X08058 P09211 X02904 P04906 3.1-fold 9 – 20 0.1-fold 1 hr
Glucocorticoid-regulated serine/threonine kinase GSK AJ000512 O00141 L01624 Q06226 0.6-fold 26 – 37 2.4-fold 3 days
        0.05-fold 21 days
Glucose Transporter 1 K03195 P11166 M13979 P11167 0.6-fold 26 – 37 11.6-fold 4 h – 21 d
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BMC Neuroscience

ISSN: 1471-2202

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