Figure 6

Behavioral responses of forebrain selective β3 knockouts. A. Spontaneous locomotor activity was measured and expressed in arbitrary units over a 10 min assessment period. Forebrain selective knockout mice were found to exhibit a statistically significant increase in total activity compared to cre- control mice. When the ambulatory component of total activity was examined, there was a trend for increased activity (p = 0.067). B. Passive avoidance. Shown is the latency to enter the dark side of the test apparatus expressed as the difference in latency between day 2 and day 1. Mice were exposed to a mild footshock (0.4 mA, 3 sec) on day 1. Separate groups of animals were also tested under identical conditions except they did not receive the footshock on day 1. Footshock increased the latency to enter (p ≤ 0.0001), but genotype and the interaction of genotype with footshock were not significant. *p < 0.05