Figure 2

Multiple amino acid sequence alignment of PSEN2. The alignment was performed using Clustal W. The sequences are Sus scrofa (DQ853415), Bos taurus (NM 174440), Homo sapiens (NM 000447), and Mus musculus (NM 011183). An asterisk (*) indicates conserved amino acids among the sequences, whereas amino acid discrepancies are marked in bold. Above the sequence alignments are by (+) indicated the position of pathogenic missense mutations identified in human PSEN2. Also the position of a human missense SNP is indicated above the sequence alignments with the alternative amino acid in bold. Furthermore, the 9 transmembrane domains are depicted in cyan according to the transmembrane prediction programme HMMTOP [33], whereas amino acid discrepancies are marked in bold.