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Figure 1 | BMC Neuroscience

Figure 1

From: Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

Figure 1

Multiple amino acid sequence alignment of PSEN1. The alignment was performed using Clustal W. The sequences are Sus scrofa (DQ853416), Bos taurus (NM 174721), Homo sapiens (NM 000021), and Mus musculus (NM 008943). An asterisk (*) indicates amino acids conserved among the sequences, whereas amino acid discrepancies are marked in bold. Above the sequence alignments are by (+) indicated the position of pathogenic missense mutations identified in human PSEN1. Also the position of human missense SNPs are indicated above the sequence alignments with the alternative amino acids in bold. Furthermore, the 9 transmembrane domains are depicted in cyan according to literature [32] and the transmembrane prediction programme HMMTOP [33]. Moreover, the amino acid residues representing the C-terminal loop are shown in yellow. The blue color represents the fragment, which has been subjected to a SNP screening in the pig.

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