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Table 3 Contractile properties of the MCAs.

From: Protein kinase C inhibition attenuates vascular ETBreceptor upregulation and decreases brain damage after cerebral ischemia in rat

 

Control

   

Ro-32-0432

   
 

RMCA

 

LMCA

 

RMCA

 

LMCA

 
 

Emax(%)

pEC50

Emax(%)

pEC50

Emax(%)

pEC50

Emax(%)

pEC50

S6c

21 ± 4

8.38 ± 0.30

3 ± 2**

6.81 ± 0.01*

7 ± 2*

7.43 ± 0.59

5 ± 3**

6.89 ± 0.16

ET-1

238 ± 19

7.62 ± 0.14

253 ± 28

7.49 ± 0.13

278 ± 11

7.54 ± 0.09

187 ± 12†

7.72 ± 0.31

  1. Contractile responses to sarafotoxin 6c (S6c) and endothelin-1 (ET-1) in the right and the left MCA 24 hours after MCAO. Emax is expressed as percent of K+ induced contractions and pEC50 values represent negative logarithm of the agonist concentration producing half maximum response. *P < 0.05, **P < 0.01 compared to control RMCA. †P < 0.05 compared to Ro-32-0432 RMCA.
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BMC Neuroscience

ISSN: 1471-2202

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