Figure 6
From: Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity
Summary of depotentiation and repotentiation effects. (A) Key, defining the measurements used. The experiment model indicates the three types of plasticity, LTP, depotentiation, and repotentiation, subjected to measurements at times (1), (2) and (3), respectively. Additionally, there are three types of experiment with different drug treatment: normal (n = 12), NR2B block (by Ro25-6981/Ifenprodil, n = 6) and NR2A block (by NVP-AAM077, n = 5), denoted a-c and corresponding to panels A-C in Fig. 5 (same primary data used). Since drugs were applied after LTP induction only depotentiation and repotentiation were subjected to the specific subunit blockers. (B) Values of field EPSPs are estimated as test responses in percentage of initial baseline under the three different experimental conditions (a-c) and time points (1–3). (C) Same as B but values are calculated as the ratio between test and control responses for the three types of experiment. Data are expressed as mean ± S.E.M.