Spinal cord dorsal horn | S1 area of cortex | Hippocampus | |||||||
---|---|---|---|---|---|---|---|---|---|
Naïve | Saline | Bee venom | Naïve | Saline | Bee venom | Naïve | Saline | Bee venom | |
5 min | |||||||||
Ipsil | 0.01 ± 0.01 | 1.40 ± 0.74* | 1.32 ± 0.51† | 0.43 ± 0.08 | 1.03 ± 0.31 | 0.85 ± 0.18 | 0.53 ± 0.18 | 0.61 ± 0.29 | 0.81 ± 0.13 |
Contl | 0.02 ± 5.12 × 10-3 | 1.80 ± 0.36** | 1.93 ± 0.36†† | 0.36 ± 0.05 | 0.86 ± 0.20 | 0.79 ± 0.18 | 0.58 ± 0.18 | 0.52 ± 0.23 | 0.77 ± 0.31 |
15 min | |||||||||
Ipsil | 9.51 × 10-3 ± 3.94 × 10-3 | 1.21 ± 0.40* | 0.56 ± 0.15† | 0.37 ± 0.10 | 0.91 ± 0.17 | 0.64 ± 0.22 | 0.55 ± 0.21 | 0.70 ± 0.10 | 0.67 ± 0.24 |
Contl | 0.01 ± 7.74 × 10-3 | 1.50 ± 0.31** | 1.31 ± 0.28†† | 0.37 ± 0.04 | 0.75 ± 0.20 | 0.79 ± 0.15 | 0.49 ± 0.14 | 0.62 ± 0.18 | 0.71 ± 0.16 |
30 min | |||||||||
Ipsil | 6.09 × 10-3 ± 1.20 × 10-3 | 0.93 ± 0.29 | 1.08 ± 0.40† | 0.25 ± 0.10 | 0.72 ± 0.22 | 0.59 ± 0.20 | 0.49 ± 0.19 | 0.64 ± 0.27 | 0.79 ± 0.25 |
Contl | 0.03 ± 0.02 | 1.45 ± 0.30* | 1.34 ± 0.32† | 0.26 ± 0.06 | 0.78 ± 0.22** | 0.81 ± 0.12†† | 0.46 ± 0.17 | 0.52 ± 0.06 | 0.69 ± 0.07 |
1 h | |||||||||
Ipsil | 0.01 ± 7.56 × 10-3 | 1.16 ± 0.46* | 1.00 ± 0.30† | 0.16 ± 0.08 | 0.89 ± 0.45 | 0.91 ± 0.33 | 0.38 ± 0.17 | 1.04 ± 0.34 | 1.22 ± 0.27 |
Contl | 0.06 ± 0.04 | 1.33 ± 0.20** | 1.26 ± 0.20†† | 0.15 ± 0.07 | 0.67 ± 0.27 | 0.55 ± 0.22 | 0.44 ± 0.15 | 1.13 ± 0.40 | 5.29 ± 4.20 |
2 h | |||||||||
Ipsil | 9.31 × 10-3 ± 2.83 × 10-3 | 1.35 ± 0.16* | 1.21 ± 0.41† | 0.22 ± 0.11 | 0.62 ± 0.15* | 0.52 ± 0.04† | 0.47 ± 0.19 | 1.08 ± 0.12* | 1.43 ± 0.17†† |
Contl | 0.03 ± 0.02 | 1.21 ± 0.19* | 1.52 ± 0.40†† | 0.22 ± 0.10 | 0.53 ± 0.12* | 0.65 ± 0.11† | 0.46 ± 0.17 | 1.19 ± 0.27 | 1.14 ± 0.31 |
4 h | |||||||||
Ipsil | 0.03 ± 0.03 | 0.69 ± 0.19* | 0.76 ± 0.25† | 0.25 ± 0.07 | 0.73 ± 0.17* | 0.77 ± 0.14† | 0.61 ± 0.31 | 0.94 ± 0.28 | 1.38 ± 0.13 |
Contl | 0.02 ± 9.34 × 10-3 | 1.11 ± 0.12** | 1.40 ± 0.33†† | 0.40 ± 0.05 | 0.93 ± 0.23* | 1.10 ± 0.23† | 0.55 ± 0.16 | 0.74 ± 0.05 | 1.00 ± 0.16 |
6 h | |||||||||
Ipsil | 0.03 ± 0.01 | 0.67 ± 0.16** | 0.63 ± 0.14†† | 0.34 ± 0.08 | 1.19 ± 0.44 | 0.78 ± 0.13 | 0.75 ± 0.18 | 1.38 ± 0.36 | 1.52 ± 0.27 |
Contl | 0.02 ± 6.72 × 10-3 | 1.20 ± 0.09*** | 1.19 ± 0.14††† | 0.32 ± 0.05 | 1.34 ± 0.63 | 0.93 ± 0.18 | 0.67 ± 0.17 | 1.85 ± 0.57 | 1.49 ± 0.20 |
12 h | |||||||||
Ipsil | 3.31 × 10-3 ± 1.67 × 10-3 | 0.75 ± 0.18** | 0.73 ± 0.09†† | 0.26 ± 0.04 | 0.82 ± 0.24 | 0.87 ± 0.20 | 0.55 ± 0.24 | 1.15 ± 0.27 | 1.27 ± 0.14 |
Contl | 0.04 ± 5.41 × 10-3 | 1.38 ± 0.19** | 1.58 ± 0.42†† | 0.19 ± 0.05 | 1.43 ± 0.63 | 1.64 ± 0.58 | 0.64 ± 0.17 | 2.11 ± 0.89 | 1.63 ± 0.14 |
24 h | |||||||||
Ipsil | 2.81 × 10-3 ± 7.82 × 10-4 | 0.81 ± 0.16** | 0.79 ± 0.15†† | 0.11 ± 0.04 | 1.12 ± 0.59 | 2.07 ± 1.45 | 0.44 ± 0.17 | 1.13 ± 0.40 | 1.00 ± 0.28 |
Contl | 0.01 ± 7.74 × 10-3 | 1.58 ± 0.34* | 1.06 ± 0.15† | 0.09 ± 0.03 | 1.75 ± 0.47 | 2.22 ± 1.74 | 0.61 ± 0.33 | 2.77 ± 0.93 | 1.24 ± 0.23 |
48 h | |||||||||
Ipsil | 3.65 × 10-3 ± 2.52 × 10-3 | 0.74 ± 0.26 | 0.90 ± 0.34† | 0.18 ± 0.06 | 0.56 ± 0.23 | 0.48 ± 0.15 | 0.56 ± 0.27 | 1.22 ± 0.18 | 0.76 ± 0.08 |
Contl | 0.08 ± 0.07 | 1.63 ± 0.21* | 2.07 ± 0.66† | 0.07 ± 0.01 | 0.65 ± 0.38 | 0.73 ± 0.36 | 0.70 ± 0.38 | 1.22 ± 0.09 | 0.86 ± 0.27 |