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Table 1 Region- or state-related differences in activation of ERK1 in naïve and pain-experiencing rats.

From: Region- or state-related differences in expression and activation of extracellular signal-regulated kinases (ERKs) in naïve and pain-experiencing rats

  Spinal cord dorsal horn S1 area of cortex Hippocampus
  Naïve Saline Bee venom Naïve Saline Bee venom Naïve Saline Bee venom
5 min          
   Ipsil 2.61 × 10-3 ± 2.21 × 10-3 0.50 ± 0.11* 0.54 ± 0.20† 2.80 × 10-3 ± 2.80 × 10-3 2.56 ± 1.83 1.08 ± 0.38 0.04 ± 0.03 0.58 ± 0.33 0.93 ± 0.44
   Contl 0.02 ± 0.01 0.57 ± 0.31 0.52 ± 0.32 3.32 × 10-3 ± 3.32 × 10-3 0.84 ± 0.30* 0.61 ± 0.24† 0.17 ± 0.13 0.87 ± 0.31 0.81 ± 0.28
15 min          
   Ipsil 8.49 × 10-4 ± 5.49 × 10-4 0.47 ± 0.08** 0.44 ± 0.09†† 1.63 × 10-3 ± 1.63 × 10-3 0.93 ± 0.30* 0.49 ± 0.23† 0.02 ± 0.01 0.60 ± 0.42 0.55 ± 0.30
   Contl 0.02 ± 0.02 0.34 ± 0.12** 0.30 ± 0.07†† 2.61 × 10-4 ± 2.61 × 10-4 0.63 ± 0.28* 0.95 ± 0.40† 0.07 ± 0.04 0.40 ± 0.08* 0.32 ± 0.08†
30 min          
   Ipsil 2.50 × 10-3 ± 1.98 × 10-3 0.36 ± 0.01*** 0.32 ± 0.05††† 1.14 × 10-3 ± 1.14 × 10-3 0.52 ± 0.16* 0.51 ± 0.20† 4.16 × 10-3 ± 3.43 × 10-3 0.50 ± 0.19* 0.72 ± 0.10†
   Contl 0.01 ± 0.01 0.27 ± 0.10 0.25 ± 0.08 4.93 × 10-4 ± 4.93 × 10-4 0.95 ± 0.16* 1.48 ± 0.58† 0.03 ± 0.01 0.38 ± 0.13* 0.75 ± 0.13†
1 h          
   Ipsil 8.45 × 10-4 ± 7.28 × 10-4 0.64 ± 0.32 0.67 ± 0.26 0 0.65 ± 0.34 0.29 ± 0.07 3.95 × 10-3 ± 3.40 × 10-3 0.64 ± 0.50 0.58 ± 0.42
   Contl 7.89 × 10-3 ± 6.95 × 10-3 0.36 ± 0.04** 0.29 ± 0.06†† 0 0.48 ± 0.28** 0.52 ± 0.22†† 0.02 ± 0.02 0.62 ± 0.41 2.23 ± 1.79
2 h          
   Ipsil 4.71 × 10-4 ± 4.48 × 10-4 0.57 ± 0.10* 0.71 ± 0.22† 2.61 × 10-4 ± 2.61 × 10-4 1.07 ± 0.68 0.56 ± 0.40 0.02 ± 0.02 0.49 ± 0.22 0.66 ± 0.28
   Contl 5.99 × 10-3 ± 4.26 × 10-3 0.27 ± 0.07 0.38 ± 0.15† 0 0.57 ± 0.13* 0.55 ± 0.06† 0.03 ± 0.03 0.52 ± 0.18 0.49 ± 0.28
4 h          
   Ipsil 5.53 × 10-4 ± 3.33 × 10-4 0.44 ± 0.16 0.53 ± 0.21 0 0.65 ± 0.37 0.82 ± 0.52 0.05 ± 0.03 0.37 ± 0.08* 0.59 ± 0.12†
   Contl 2.40 × 10-3 ± 1.43 × 10-3 0.35 ± 0.11* 0.34 ± 0.09† 0.07 ± 0.06 1.32 ± 0.48* 1.08 ± 0.16† 0.07 ± 0.05 0.33 ± 0.04 0.52 ± 0.25
6 h          
   Ipsil 1.13 × 10-3 ± 5.75 × 10-4 0.60 ± 0.22 0.49 ± 0.21 6.79 × 10-4 ± 6.79 × 10-4 0.37 ± 0.09** 0.42 ± 0.03†† 0.04 ± 0.02 1.38 ± 0.83 1.58 ± 0.68
   Contl 6.00 × 10-3 ± 5.12 × 10-3 0.49 ± 0.06*** 0.44 ± 0.03††† 0.08 ± 0.08 0.91 ± 0.53 0.60 ± 0.42 0.08 ± 0.06 1.25 ± 0.30* 0.93 ± 0.17†
12 h          
   Ipsil 1.59 × 10-3 ± 8.16 × 10-4 0.53 ± 0.24* 0.62 ± 0.18† 0 0.53 ± 0.19** 0.54 ± 0.17†† 7.94 × 10-3 ± 5.17 × 10-3 0.75 ± 0.09*** 0.85 ± 0.16†††
   Contl 1.49 × 10-3 ± 6.99 × 10-4 0.45 ± 0.05*** 0.43 ± 0.06††† 4.17 × 10-4 ± 4.17 × 10-4 0.71 ± 0.46 1.02 ± 0.61 0.09 ± 0.09 1.16 ± 0.44* 1.28 ± 0.21†
24 h          
   Ipsil 7.32 × 10-4 ± 4.13 × 10-4 0.63 ± 0.15* 0.53 ± 0.26† 0 0.62 ± 0.29 1.93 ± 1.52 1.97 × 10-4 ± 1.97 × 10-4 1.28 ± 0.70 0.87 ± 0.40
   Contl 1.74 × 10-3 ± 8.96 × 10-4 0.39 ± 0.09** 0.35 ± 0.05†† 5.15 × 10-4 ± 5.15 × 10-4 1.42 ± 0.52* 0.48 ± 0.05† 0.05 ± 0.05 2.02 ± 0.72 0.97 ± 0.22
48 h          
   Ipsil 5.66 × 10-4 ± 3.37 × 10-4 0.33 ± 0.14 0.38 ± 0.18 1.84 × 10-3 ± 1.84 × 10-3 0.08 ± 0.04 0.16 ± 0.04† 7.45 × 10-3 ± 5.32 × 10-3 0.76 ± 0.02*** 0.50 ± 0.04†††
   Contl 6.04 × 10-3 ± 4.18 × 10-3 0.14 ± 0.02* 0.24 ± 0.05††† 6.85 × 10-4 ± 6.85 × 10-4 0.90 ± 0.83 0.88 ± 0.82 5.59 × 10-3 ± 5.32 × 10-3 0.65 ± 0.16* 0.36 ± 0.08†
  1. Notes: Data are mean ± SEM. for the immunoblotted band intensities of phospho-ERK1 normalized to those of the loading control (total ERK1) obtained from three rats per group. Values from ipsilateral (Ipsil.) and contralateral (Contl.) sides of three indicated areas at ten time points are shown. * P < 0.05, ** P < 0.01, *** P < 0.001, saline-treated rats versus naïve control. † P < 0.05, †† P < 0.01, ††† P < 0.001, bee venom-treated rats versus naïve control.