Figure 2From: Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transportVP22 enhanced microdystrophin gene expression and distribution in mdx mice. (A) The effect of VP22 was reflected in the level of microdystrophin expression in pAMICDYS (a) and pAVP22-MICDYS (b) injected the left TA muscles. Microdystrophin -positive fibers were detected in both groups, but the number of microdystrophin-positive fibers and the intensity of immunofluorescence were uniformly greater in pAVP22-MICDYS injected TA muscles. Magnification: × 100. (B) Immunostaining analysis microdystrophin expression in mdx mouse TA injected by pAMICDYS (c, f) or pAVP22 -MICDYS (b, e) at 2 weeks (b, c) and 16 weeks (e, f) after injection, the right TA injected by PBS (d). The TA of C57BL/10 (a). Magnification: × 200.Back to article page