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Figure 8 | BMC Neuroscience

Figure 8

From: Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors

Figure 8

Model for a balance between PTPs such as SHP-2 and kinases such as SFKs, which stabilizes postsynaptic AChR clusters. Process A, stabilization: MuSK-bound and activated SHP-2 could activate SFKs, leading to AChR β phosphorylation, stable AChR-rapsyn (rap) interaction and phosphorylation of cytoskeletal regulators (e.g. actin-controlling proteins such as the SFK-substrates cortactin, p190RhoGAP or WASp). Process B, destabilization: SHP-2 may dephosphorylate AChR β and the cytoskeletal regulators. A balance between A and B keeps clusters intact. UGC, utrophin-glycoprotein complex: an array of proteins that stabilize the postsynaptic apparatus. Members of this complex interact with rapsyn (β-dystroglycan) and actin (utrophin).

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BMC Neuroscience

ISSN: 1471-2202

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