Figure 2

Brain expression differences between pools of narcoleptic and heterozygous dogs, determined by microarray analysis. Average differences in gene expression between six narcoleptic dogs and six unaffected siblings, heterozygous for the canarc-1 mutation, for three regions of the brain. For each of the 29 760 human cDNA clones both the average expression difference (M) and the ranking statistic (penalized F-ratio) is shown for pair-wise comparisons. Twenty two clones with a penalized F-ratio above five (marked in black) showed a significant expression difference between narcoleptic and heterozygous individuals (false discovery rate, FDR < 0.29).