Figure 5

Average kinetics of TMR-labelled peptide association with live NGF differentiated PC12 cells. Aβ42 (solid line) revealed an initial rapid binding phase within the first hour, followed by a slower binding phase over the next 24 hours. Aβ40 (dashed line) did not display the initial rapid binding phase, but was otherwise similar to Aβ42. The mutant peptide (dotted line) did not interact with the live NGF differentiated PC12 cells. This finding suggests a correlation between aggregation propensity and cell association for Aβ.