Figure 5
From: Pigment epithelium-derived factor protects retinal ganglion cells
Protective effect of PEDF against trophic factor withdrawal-induced RGC toxicity. (A) Cells were treated with the indicated concentrations of PEDF in the presence or absence of trophic factors (n = 6). (B) Effects of various compounds on the PEDF protection against trophic factor withdrawal-induced cytotoxicity. Numbers on the bars represent sample sizes. TFW = trophic factor withdrawal. (C and D) Concentration-dependent reversal of the PEDF protection by NFκB inhibitor NFκB-SN50 and ERK1/2 inhibitor PD98059, respectively. Three trophic factors, bFGF, BDNF, and CNTF were removed from the culture medium in the trophic factor withdrawal group. * represents P < 0.05 vs. the respective control group by One-way ANOVA then Dunnett's test.