Figure 4
From: Pigment epithelium-derived factor protects retinal ganglion cells
Protective effect of PEDF against glutamate-induced RGC toxicity. (A) Cells were treated with the indicated concentrations of PEDF in the presence or absence of 100 μM of glutamate (n = 6). (B) Effects of various compounds on PEDF protection against excitotoxicity. Numbers on the bars represent sample sizes. (C and D) Concentration-dependent reversal of the PEDF protection by NFκB inhibitor NFκB-SN50 and ERK1/2 inhibitor PD98059, respectively. * represents P < 0.05 vs. the respective control group by One-way ANOVA then Dunnett's test. Glu = glutamate.