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Table 3 Biosynthesis of NMDA from D-Asp and other amino acids in the nervous tissues of the amphioxus Branchiostoma lanceolatum.

From: N-Methyl-D-aspartic Acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum

Amino acid *

Tissue

 

Nerve Cord

Cephalic Vesicle/Hindbrain

Muscle

 

NMDA synthesized (nmol/g tissues)

D-Asp

33.4 ± 4.3

45.5 ± 5.4

1.5 ± 0.4

L-Asp

3.4 ± 0.4

3.2 ± 0.6

0.8 ± 0.2

D-Glu

3.8 ± 0.5

2.3 ± 0.4

0.7 ± 0.1

L-Glu

3.5 ± 0.4

2.1 ± 0.4

0.6 ± 0.1

D-Ala

3.2 ± 0.3

2.2 ± 0.3

0.5 ± 0.2

L-Ala

3.3 ± 0.4

3.2 ± 0.6

0.8 ± 0.2

D-Ser

2.9 ± 0.4

2.6 ± 0.4

0.6 ± 0.2

L-Ser

3.5 ± 0.6

1.7 ± 0.2

0.7 ± 0.2

Gly

3.6 ± 0.4

1.9 ± 0.5

0.6 ± 0.2

Control

3.1 ± 0.4

2.3 ± 0.4

0.5 ± 0.1

  1. * Tissues were incubated with the amino acids listed in the table and SAM, according to the method described in the "Methods" section. Results are the mean ± S.D. obtained from 3 experiments.