Figure 3

Gene ontology categories for the genes most highly expressed in both SCG and DRG. Major gene ontology categories for the genes most highly expressed in both SCG and DRG are colored by probe intensity (same color scheme as Figure 2B), including where available their cellular localization and prior evidence of association with regeneration (triangles). (A) Diagram of a neuron with localization of function for 82 of the 325 genes in the top 5% intersection of genes most highly expressed in both DRG and SCG. A triangle to the left of a transcript indicates a gene previously linked to regeneration (see references in text), and triangle to the right of a transcript indicates that another subunit or isoform of this gene was previously linked to regeneration. Gene names are listed in Additional file 2. (B) Lists the major Gene Ontology terms found by MAPPFinder for the top 2% intersection of both DRG and SCG expression levels. To the right of each GO term is the number of genes found in this group relative to the rest of the dataset. All observations had a Z-score > 2 and permuted-p ≤ 0.05. Terms in parentheses show related categories that were also significant, and those in bold had a p-value ≤ 0.05 after adjustment for multiple hypothesis testing.