Figure 2

Meta-analysis of genes changed during in vivo models of regeneration. (A) Venn diagram of genes affected in common across in vivo regeneration models. Data from three published studies of in vivo regeneration after peripheral axotomy in adult rats were compared to each other. Those genes found by two or more of these studies (shaded regions of overlap, n = 78) are also noted on the clusters found in Figure 1 and in Additional file 1 (Additional Figures 2 and 3). All genes were mapped to a common Entrez Gene ID, which is listed in Additional file 2 along with associated data. (B) Scatter plot of median intensity in both DRG and SCG for each unique Entrez gene found in this study. Probesets were collapsed to select only one unique Entrez ID per gene, so that genes with multiple probesets on the array would not skew the data. Blue, green, and yellow points highlight genes whose intensity of expression are respectively in the top 5%, 2%, and 1% intersection of all DRG- and SCG-expressed genes. Further annotation of these highly-expressed transcripts is found in Figure 3. DRG in vivo¹, rat gene regulated 3 days after sciatic nerve axotomy (n = 187) [21]. DRG in vivo², rat gene regulated 2 days after sciatic nerve axotomy (n = 88) [23]. SCG in vivo³, rat gene regulated 2 days after post-ganglionic nerve axotomy (n = 230) [19].