TY - JOUR AU - Alberghina, Lilia AU - Colangelo, Anna Maria PY - 2006 DA - 2006/10/30 TI - The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration JO - BMC Neuroscience SP - S2 VL - 7 IS - 1 AB - Apoptosis is a programmed cell death that plays a critical role during the development of the nervous system and in many chronic neurodegenerative diseases, including Alzheimer's disease (AD). This pathology, characterized by a progressive degeneration of cholinergic function resulting in a remarkable cognitive decline, is the most common form of dementia with high social and economic impact. Current therapies of AD are only symptomatic, therefore the need to elucidate the mechanisms underlying the onset and progression of the disease is surely needed in order to develop effective pharmacological therapies. Because of its pivotal role in neuronal cell death, apoptosis has been considered one of the most appealing therapeutic targets, however, due to the complexity of the molecular mechanisms involving the various triggering events and the many signaling cascades leading to cell death, a comprehensive understanding of this process is still lacking. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-7-S1-S2 DO - 10.1186/1471-2202-7-S1-S2 ID - Alberghina2006 ER -