Figure 6

Signaling network in neurons Schematic overview of signaling pathway modules in neuronal cells (redrawn from Bhalla [82]). Abbreviations: RTK: receptor tyrosine kinase; mGluR: metabotropic glutamate recptor; GPCR: G-protein coupled receptor; NMDAR: N-methyl D-aspartate Receptor; Gq: G-protein type q; Gsα: G-protein type s; PLCβ: phospholipase C β; PLCγ: phospholipase C γ; IP3: inositol trisphosphate; DAG: diacylglycerol; Sos/GEF: Son of Sevenless/guanine nucleotide exchange factor; Ca²⁺ : Calcium; PKC: protein kinase C; AC: adenylyl cyclase; PDE: phosphodiesterase; CaM: calmodulin; CaMKII: calcium calmodulin kinase type II; cAMP: cyclic adenosine monophosphate; CaN: calcineurin; AA: arachidonic acid; PLA₂: phospholipase A2; MAPK: mitogen activated protein kinase; MKP-1: MAP-Kinase phosphatase type 1; PKA: protein kinase A; PP1: protein phosphatase type 1.