Phenotype | Percent Difference YAC128 Compared to WT | Percent Difference YAC18/128 Compared to WT | Percent Rescue with WT htt Expression | Significance |
---|---|---|---|---|
Rotarod | -36% | -41% | None | p = 0.5 |
Activity – 2 Months | +6% | +2% | 74% | P = 0.5 |
Activity – 12 Months | -10% | -6% | 47% | P = 0.5 |
Striatal Volume | -9% | -7% | 21% | p = 0.3 |
Striatal Neuronal Counts | -6% | -3% | 38% | p = 0.4 |
Striatal DARPP-32 Expression | -18% | -14% | 22% | p = 0.3 |
Striatal Neuronal Size | -12% | -2% | 87% | p < 0.001 |