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Table 1 Effect of modulating wild-type huntingtin levels on survival in YAC128 mice.

From: Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

Sex

Genotype

Deaths

Total Mice

Percent Surviving

Males

WT

4

46

91%

 

YAC18/128

3

11

73%

 

YAC128

12

48

75%

 

YAC128-/-

11

15

27%

Females

WT

5

42

88%

 

YAC18/128

0

4

100%

 

YAC128

5

66

92%

 

YAC128-/-

3

19

84%

  1. YAC128-/- mice express mutant htt and no wild-type htt. YAC128 mice express mutant htt and 2 copies of wild-type htt. YAC18/128 express mutant htt and increased levels of wild-type htt.