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Figure 2 | BMC Neuroscience

Figure 2

From: Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

Figure 2

Over-expression of wild-type htt results in mild improvements in striatal neuropathology in YAC128 mice. Comparison of striatal phenotypes between YAC128 and YAC18/128 mice revealed that over-expression of wild-type htt resulted in no significant change in striatal volume (panel A: YAC128: 11.3 ± 0.2 mm2, YAC18/128: 11.6 ± 0.2 mm2, p = 0.3), striatal neuronal counts (panel B: YAC128: 1.56 ± 0.03 million neurons, YAC18/128: 1.59 ± 0.03 million neurons, p = 0.4) or striatal DARPP-32 expression (panel C: YAC128: 828 ± 28 arbitrary units, YAC18/128: 868 ± 22 arbitrary units, p = 0.3). In contrast, over-expression of wild-type htt resulted in a significant improvement in striatal neuronal cross-sectional area (panel D: YAC128: 96.2 ± 1.6 um2, YAC18/128: 108 ± 1.9 um2, p < 0.001). For each outcome measure, YAC128 mice show a significant deficit compared to WT mice. N = 17 WT, 17 YAC128, 14 YAC18, 17 YAC18/128 except for striatal DARPP-32 expression where N = 10 WT, 12 YAC128, 10 YAC18, 8 YAC18/128. Error bars show standard error of the mean. ** p < 0.01. *** p < 0.001.

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BMC Neuroscience

ISSN: 1471-2202

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