Figure 7

Expresssion of SCG10 after LPS application. Coronal sections of motor cortex immunoreacted for SCG10 (except for insets), 1 week (Figs 7a – d) and 1 month (Figs 7e, f) after LPS application. Control, contralateral cortex is shown in Figs 7a, c and e, LPS-treated cortex in Figs 7b, d and f. Note increased SCG10 immunoreactivity in layer V cells at one week in Fig. 7b compared to contralateral cortex (Fig. 7a), and absence of immunoreactivity in more superficial cortex. Fig. 7c is enlarged from layer V in Fig. 7a and Fig. 7d is enlarged from layer V in Fig. 7b. One month after LPS application there is only a background level of SCG10 immunoreactivity in layer V cells of both contralateral (Fig. 7e) and ipsilateral (Fig. 7f) cortex. The insets are from immediately serial sections to Figs 7e and 7f and show retrogradely CTB-labelled CST neurons in layer V. Bar in Fig. 7a = 200 μm and also applies to Figs 7b, e, f and insets; bar in Fig. 7c = 50 μm and also applies to Fig. 7d.