DCX-expressing cells in the subgranular zone. Column A, C, D shows normal conditions, column B, D, F shows conditions after induction of seizures by kainate application. A and C, DCX-positive cells in the subgranular zone (SGZ) with dendrites of various lengths reaching into the molecular layer. The nucleus appears usually devoid of immunoreaction. The granule cell layer is seen as a light band. Scale bar (in B for all panels), 150 μm. Insert, high power depiction of a cluster of DCX-positive cells of different morphology. Note, how the initial segment of the dendrite grows parallel to the SGZ. Scale bar, 45 μm. B and D, Kainate application increases the number of DCX-positive cells in the SGZ (here at 10 days after seizure induction). The SGZ widens and occasionally shows a bi-layered structure. Scale bar, 150 μm. E and F, Kainate injections increase the number of DCX-positive cells but do not seem to cause abnormal growth of the apical dendrites. Scale bar, 80 μm.