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Figure 8 | BMC Neuroscience

Figure 8

From: Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

Figure 8

17β-estradiol prevents calcium-induced damage to mitochondrial respiratory function. A. Whole brain mitochondria were isolated from ovariectomized rats and assessed for mitochondrial respiration in the presence of glutamate (5 μM) and malate (5 μM) as respiratory substrates following a 2 min challenge with 100 μM Ca2+ or buffer control. Respiratory control ratio (RCR) is the ratio of State 3 (ADP stimulated) respiration to State 4 (resting) respiration. (n = 7; * = p < 0.05) B. Whole brain mitochondria were isolated from ovariectomized rats treated with 17β-estradiol (30 μg/kg) or vehicle control for 24 hr and assessed for mitochondrial respiration following 2 min calcium (10 μM) exposure in the presence of glutamate (5 μM) and malate (5 μM) as respiratory substrates. C. Respiratory control ratio (RCR) is the ratio of State 3 (ADP stimulated) respiration to State 4 (resting) respiration. (n = 7; * = p < 0.05)

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