Figure 7
17β-estradiol prevents Amyloid beta1–42-induced Bax translocation and cytochrome c release. Primary hippocampal neurons pretreated with E2 (10 ng/mL; 48 hr) or vehicle control were exposed to Aβ1–42 for 24 hr and assessed for Bax and cytochrome c expression by immunocytochemistry. Treated neurons were double immunostained for Bax (Red) and cytochrome c expression (Green). Bar = 10 μm.