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Figure 2 | BMC Neuroscience

Figure 2

From: Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

Figure 2

17β-estradiol prevents Amyloid beta1–42-induced apoptosis. Primary hippocampal neurons pretreated with E2 (10 ng/mL; 48 hr) or vehicle control were exposed to Aβ1–42 for 3 days and assessed for apoptosis by TUNEL staining. A, Representative images of TUNEL positive neurons and total nuclei. Bar = 20 μm. B, Counts of TUNEL positive neurons normalized to total nuclei from 3 random fields per well are presented as mean ± SEM. (* = p < 0.05 as compared to control; + = p < 0.05 as compared to Aβ1–42 alone; n = 4).

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