TY - JOUR AU - Nilsen, Jon AU - Chen, Shuhua AU - Irwin, Ronald W. AU - Iwamoto, Sean AU - Brinton, Roberta Diaz PY - 2006 DA - 2006/11/03 TI - Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function JO - BMC Neuroscience SP - 74 VL - 7 IS - 1 AB - Neurodegeneration in Alzheimer's disease is associated with increased apoptosis and parallels increased levels of amyloid beta, which can induce neuronal apoptosis. Estrogen exposure prior to neurotoxic insult of hippocampal neurons promotes neuronal defence and survival against neurodegenerative insults including amyloid beta. Although all underlying molecular mechanisms of amyloid beta neurotoxicity remain undetermined, mitochondrial dysfunction, including altered calcium homeostasis and Bcl-2 expression, are involved in neurodegenerative vulnerability. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-7-74 DO - 10.1186/1471-2202-7-74 ID - Nilsen2006 ER -